CST3 and CSTB

Number of citations of the paper that reports this interaction (PubMedID 1996959)
28

Data Source:
BioGRID (enzymatic study)

		CST3	CSTB
Description		cystatin C	cystatin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation	Neutrophil degranulation
Drugs			Cupric Chloride
Diseases
GWAS		Blood protein levels ( 28240269) Chronic kidney disease ( 20383146) Cystatin C levels ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		10 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 POLE3 RNF115	11 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 ERG RAD21 RUNX1 SPRY2
Entrez ID		1471	1476
HPRD ID		05056	03091
Ensembl ID		ENSG00000101439	ENSG00000160213
Uniprot IDs		A0A0K0K1J1 P01034	P04080 Q76LA1
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?
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