CST3 and C4A

Number of citations of the paper that reports this interaction (PubMedID 2304899)
7

Data Source:
HPRD (in vitro)

		CST3	C4A
Description		cystatin C	complement C4A (Rodgers blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Complement Component C1q Complex Binding Endopeptidase Inhibitor Activity
	Biological Process	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs			Human immunoglobulin G
Diseases
GWAS		Blood protein levels ( 28240269) Chronic kidney disease ( 20383146) Cystatin C levels ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 POLE3 RNF115	8 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 HSP90AA1 MASP2
Entrez ID		1471	720
HPRD ID		05056	00401
Ensembl ID		ENSG00000101439	ENSG00000244731
Uniprot IDs		A0A0K0K1J1 P01034	P0C0L4
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV	1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW
Enriched GO Terms of Interacting Partners?
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