CSTB and CTSB

Number of citations of the paper that reports this interaction (PubMedID 26208400)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		CSTB	CTSB
Description		cystatin B	cathepsin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Intracellular Anatomical Structure Lysosome External Side Of Plasma Membrane Apical Plasma Membrane Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Viral Entry Into Host Cell Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Neutrophil degranulation	Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation
Drugs		Cupric Chloride	2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 32201043 28892059) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		11 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 ERG RAD21 RUNX1 SPRY2	37 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1
Entrez ID		1476	1508
HPRD ID		03091	00287
Ensembl ID		ENSG00000160213	ENSG00000164733
Uniprot IDs		P04080 Q76LA1	A0A024R374 B4DMY4 P07858 Q5HYG5
PDB IDs		1STF 2OCT 4N6V	1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2
Enriched GO Terms of Interacting Partners?
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