ELOVL4 and ZDHHC21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ELOVL4	ZDHHC21
Description		ELOVL fatty acid elongase 4	zinc finger DHHC-type palmitoyltransferase 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity	Protein Binding Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process	Hair Follicle Development Regulation Of Vascular Associated Smooth Muscle Contraction Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Sebaceous Gland Development Regulation Of Nitric-oxide Synthase Activity Adrenergic Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Pathways		Synthesis of very long-chain fatty acyl-CoAs	eNOS activation Extra-nuclear estrogen signaling
Drugs		Omega-3-carboxylic acids
Diseases
GWAS		Aging ( 22773346) Body mass index ( 23669352) Chronic obstructive pulmonary disease ( 28166215) Daytime sleep phenotypes ( 27126917) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Partial epilepsies ( 20522523) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first sexual intercourse ( 34211149) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Neuritic plaque ( 31497858) Schizophrenia ( 33169155) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		95 interacting genes: ADGRE2 ANKRD46 APOL3 ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 ITGAM JAGN1 LEPROTL1 LHFPL5 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SNORC STX3 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM199 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB YIF1A YIPF6 ZDHHC21 ZFPL1	12 interacting genes: AQP6 CHODL CREB3 ELOVL4 ERGIC3 FAM210B MTERF3 MUC1 PGRMC2 RNASEK TMEM167B TRIM59
Entrez ID		6785	340481
HPRD ID		05697	15716
Ensembl ID		ENSG00000118402	ENSG00000175893
Uniprot IDs		Q9GZR5	Q8IVQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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