CSF2RB and IL3RA

Number of citations of the paper that reports this interaction (PubMedID 8649415)
13

Data Source:
HPRD (in vitro)

		CSF2RB	IL3RA
Description		colony stimulating factor 2 receptor subunit beta	interleukin 3 receptor subunit alpha
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Signaling Receptor Activity	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Signal Transduction Respiratory Gaseous Exchange By Respiratory System Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway	Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Sargramostim NPI 32101 Resatorvid	Sargramostim Tagraxofusp
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)	Schizophrenia ( 17522711)
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5
Entrez ID		1439	3563
HPRD ID		00739	02392
Ensembl ID		ENSG00000100368	ENSG00000185291
Uniprot IDs		P32927 Q6NSJ8	P26951
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU	4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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