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PARP1 and PRKDC
Number of citations of the paper that reports this interaction (PubMedID
9398855
)
49
Data Source:
HPRD
(in vivo)
PARP1
PRKDC
Description
poly(ADP-ribose) polymerase 1
protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Mitochondrion
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Site Of DNA Damage
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Nonhomologous End Joining Complex
Molecular Function
DNA Binding
RNA Binding
NAD+ ADP-ribosyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Estrogen Receptor Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NAD Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Protein ADP-ribosylase Activity
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
DNA Repair
Double-strand Break Repair
Transcription By RNA Polymerase II
Protein ADP-ribosylation
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of SMAD Protein Complex Assembly
Protein Autoprocessing
Peptidyl-serine ADP-ribosylation
Peptidyl-glutamic Acid Poly-ADP-ribosylation
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
DNA Damage Response, Detection Of DNA Damage
Mitochondrial DNA Repair
Regulation Of DNA Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Catalytic Activity
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Cellular Response To Zinc Ion
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Neuron Death
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Single Strand Break Repair
Regulation Of Cellular Protein Localization
Response To Aldosterone
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
ATP Generation From Poly-ADP-D-ribose
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of ATP Biosynthetic Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
Negative Regulation Of Immunoglobulin Production
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Response To Activity
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Spleen Development
Thymus Development
Positive Regulation Of Developmental Growth
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Response To Gamma Radiation
Pathways
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Caffeine
SF1126
Diseases
GWAS
Coronary artery disease (
29212778
)
Leukocyte telomere length (
32109421
31171785
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Adult body size (
32376654
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
110 interacting genes:
APTX
ATM
BCL2
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CENPA
CENPB
CHD1L
CREBBP
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
ERCC6
ERG
ETS1
FOXO1
GTF2F1
GZMB
GZMM
H1-0
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-3A
H3-4
H4C3
HDAC1
HDAC3
HIPK2
HMGA1
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LINC00624
LZTR1
MACROH2A1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
NUDT16
OGT
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF144A
RNF168
RPS3A
RXRA
SENP1
SENP3
SIRT1
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
TP53BP1
TRIP12
UBE2I
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
91 interacting genes:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R3
PRKCD
PTEN
RAD17
RASSF1
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TOP1
TP53
TREX1
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
Entrez ID
142
5591
HPRD ID
01435
02941
Ensembl ID
ENSG00000143799
ENSG00000253729
Uniprot IDs
A0A024R3T8
P09874
P78527
PDB IDs
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6M3I
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
7AAA
7AAB
7AAC
7AAD
7CMW
7KK2
7KK3
7KK4
7KK5
7KK6
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
Enriched GO Terms of Interacting Partners
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