PARP1 and OGT

Number of citations of the paper that reports this interaction (PubMedID 32994395)
0

Data Source:
BioGRID (pull down)

		PARP1	OGT
Description		poly(ADP-ribose) polymerase 1	O-linked N-acetylglucosamine (GlcNAc) transferase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Nucleolus Mitochondrion Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Site Of DNA Damage	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Mitochondrial Membrane Protein-containing Complex Cell Projection
	Molecular Function	DNA Binding RNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Estrogen Receptor Binding Identical Protein Binding Histone Deacetylase Binding Protein N-terminus Binding NAD Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Protein O-GlcNAc Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Repair Double-strand Break Repair Transcription By RNA Polymerase II Protein ADP-ribosylation Apoptotic Process Cellular Response To DNA Damage Stimulus Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of SMAD Protein Complex Assembly Protein Autoprocessing Peptidyl-serine ADP-ribosylation Peptidyl-glutamic Acid Poly-ADP-ribosylation Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process DNA Damage Response, Detection Of DNA Damage Mitochondrial DNA Repair Regulation Of DNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Cellular Response To Zinc Ion Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Neuron Death Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Single Strand Break Repair Regulation Of Cellular Protein Localization Response To Aldosterone Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Generation From Poly-ADP-D-ribose Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of ATP Biosynthetic Process	Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Protein Processing Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Necroptotic Process Positive Regulation Of Histone H3-K27 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Cold-induced Thermogenesis
Pathways		POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases
Drugs		Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Coronary artery disease ( 29212778) Leukocyte telomere length ( 32109421 31171785) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 32341527 30429480) Platelet count ( 29403010) Telomere length ( 29151059)	Red cell distribution width ( 32888494)
Interacting Genes		110 interacting genes: APTX ATM BCL2 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CHD1L CREBBP CTCF CTSB CTSG DTX2 DUX4 E2F1 ERCC6 ERG ETS1 FOXO1 GTF2F1 GZMB GZMM H1-0 H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-3A H3-4 H4C3 HDAC1 HDAC3 HIPK2 HMGA1 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LINC00624 LZTR1 MACROH2A1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 NUDT16 OGT OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF144A RNF168 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 TP53BP1 TRIP12 UBE2I WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	725 interacting genes: - AAMP AARSD1 AASS ABI1 ABI2 ABRAXAS1 ABRAXAS2 ACOX1 ACTB ACTC1 ACTL6A ACTR3 ADPGK ADSL AGFG1 AHSA1 ALDH1A2 ALDH1B1 ALDH2 ALDH4A1 ALDH5A1 ALDH6A1 ALDH7A1 ALDOA ALKBH5 ANAPC7 ANXA11 ANXA6 ANXA7 API5 APMAP APOH ARHGAP1 ARHGAP19 ARIH2 ARMC6 ASCC1 ASPH ATAD3A ATG5 ATIC ATL2 ATL3 ATP1B1 ATP1B3 ATP5F1A ATP5F1B ATP6AP1 ATXN10 ATXN2L B3GLCT B4GAT1 BAG1 BAIAP2 BCCIP BCLAF1 BEND7 BIRC5 BSG BYSL BZW2 C17orf75 CAAP1 CALR CARS2 CASP8 CAT CAVIN1 CBLL1 CBR1 CBWD6 CCDC47 CCDC77 CCDC86 CCNB1 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 CD2BP2 CDC123 CDC37 CDC42EP1 CDC5L CDC6 CDK9 CDKAL1 CELF1 CENPU CEP43 CEP55 CEP57 CHMP7 CHST7 CIR1 CKAP4 CKB CKMT1A CLCC1 CLN5 CLPB CLPX CNDP2 CNOT11 COIL COPS2 COQ8B CPSF6 CPSF7 CREBBP CRTAP CSNK1G2 CSNK2A1 CSNK2B CTNND1 CTSD CTU2 CWC25 CWC27 CXADR DAPK3 DAZAP1 DBN1 DBNL DBT DCTN2 DDX17 DDX28 DDX39B DDX3X DDX41 DDX47 DDX5 DDX56 DEK DHX30 DHX9 DLD DLG3 DLST DMAP1 DNAJA1 DNAJA2 DNAJC3 DNAJC7 DUS1L DYNC1LI1 DYNC1LI2 EARS2 ECSIT EDC3 EEF1A1 EEF1G EHD1 EIF2AK2 EIF2S2 EIF3D EIF3E EIF3F EIF3G EIF4A1 EIF4G2 EIF5 ELOA ENO1 ERGIC3 ERI1 ERO1A ERO1B ESS2 ETF1 EWSR1 FAF2 FAM199X FAM98A FARSA FDXR FEN1 FH FIP1L1 FIZ1 FKBP10 FKBP4 FKBP5 FKBP8 FNTA FTO FTSJ3 FUBP3 FUCA1 FUCA2 FUS G3BP1 G3BP2 GABPA GAPDH GART GATA6 GATB GBA GDI1 GDI2 GLA GLB1 GLMN GLS GLUD1 GNL3 GORASP2 GPATCH4 GPKOW GPS1 GPT2 GRSF1 GRWD1 GSK3A GSK3B GSS GSTM3 GSTP1 GTF2E1 GTF2H1 GTF3C5 GTPBP3 GXYLT1 H1-4 HABP4 HARS1 HARS2 HAUS8 HCFC1 HDAC1 HGH1 HIRA HIVEP1 HMGCS1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HP1BP3 HS2ST1 HSP90AA1 HSP90AB1 HSP90B1 HSPA13 HSPA14 HSPA1A HSPA5 HSPA8 HSPA9 HSPD1 IFRD2 IGF2BP1 IGF2BP2 IGF2BP3 IGKV2D-29 IK IKBIP ILF2 ILF3 ILK ILKAP IMPDH1 IMPDH2 IPO5 IRF3 IRS4 IST1 ISYNA1 JMJD6 KARS1 KATNA1 KHDRBS1 KHDRBS3 KNOP1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 KPNB1 KRR1 KRT1 KRT10 KRT2 KRT8 KRT9 LACTB LAP3 LARP4B LDHB LEMD2 LENG9 LETM1 LMAN1 LMNA LNPK LPCAT1 LPCAT4 LRP4 LRRFIP2 LSM14A LSM14B LSR LTV1 LUC7L2 LUC7L3 LYAR MAP1A MAP7D1 MAPT MARS2 MAT2A MAZ MCCC2 ME1 ME2 MEAK7 METAP2 MFAP1 MICU1 MINPP1 MPP1 MRM3 MSTO1 MTDH MYEF2 NAE1 NAMPT NAP1L1 NAP1L4 NASP NCL NDUFV1 NELFCD NISCH NKAP NOC4L NOLC1 NOM1 NONO NOP53 NOP58 NPM1 NSMCE4A NSUN5 NSUN6 NT5DC1 NUDC NUF2 NUFIP1 NUFIP2 NUP50 NUP54 NUP62 NUP62CL NUSAP1 NXN OAT OCLN OGA OLA1 OXCT1 OXSR1 P3H4 P4HA1 P4HA2 P4HB PA2G4 PABPC1 PABPC4 PABPN1 PACSIN3 PAIP1 PAK2 PALS2 PARD6B PARP1 PARVA PCBP1 PCBP2 PCGF2 PCGF6 PCYOX1 PDCD2L PDCD4 PDCD7 PDHX PDIA3 PDIA5 PDIA6 PDP1 PEX14 PGD PGK1 PGM1 PHAX PHC3 PHF10 PHF6 PHGDH PI4K2A PICALM PIP4K2C PKM PKP4 PLD3 PLEKHO1 PLIN2 PLS3 PM20D2 PMPCA PNKP PNMA8A POGLUT3 POLD2 POLDIP3 POLM POLR1E POLR3C POLR3D POMK PPAT PPHLN1 PPM1F PPP1R7 PPP2R1A PPP2R1B PPP2R5C PPP2R5E PPP3CA PPP5C PRC1 PRCP PRIM1 PRIM2 PRKAR1A PRKAR2A PRKAR2B PRORP PRPF19 PRPF31 PRRC1 PSG1 PSIP1 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD12 PSMD4 PSPC1 PTBP1 PTBP2 PUF60 PURA PWP1 QRSL1 RAB11FIP2 RAD23A RAD23B RANGAP1 RAP1GDS1 RARS1 RARS2 RBBP4 RBBP7 RBFOX2 RBM14 RBM17 RBM22 RBM23 RBM39 RBM42 RBM45 RBMS1 RBMX RCC1 RCN2 REPIN1 REXO4 RIC8A RING1 RIOX2 RNH1 RNPS1 RO60 RPL10 RPL10A RPL11 RPL12 RPL13 RPL22 RPL24 RPL3 RPL30 RPL4 RPL5 RPL6 RPL7 RPL8 RPL9 RPLP0 RPS2 RPS24 RPS3 RPS3A RPS4X RPS7 RPSA RRP1 RRP1B RRP8 RRS1 RSRC2 RTCB RTN4 RUVBL1 RUVBL2 SAAL1 SAP30BP SARS1 SARS2 SCAI SCLY SCP2 SCRIB SCRN1 SDE2 SEC62 SENP2 SEPTIN11 SEPTIN7 SERBP1 SERPINH1 SETD7 SF1 SF3A2 SF3A3 SF3B4 SFPQ SGSH SH3GLB2 SHMT2 SHOC2 SIN3A SLC9A3R1 SLIT2 SMARCD1 SMARCD2 SMARCE1 SMPDL3B SNAP91 SNRNP70 SNW1 SNX4 SNX5 SNX6 SP1 SPAST SPATS2 SPATS2L SPOUT1 SQSTM1 SRF SRFBP1 SRP54 SRP68 SRP72 SRSF11 SRSF6 SRSF7 SSB ST13 STAU1 STAU2 STIP1 STK24 STK25 STK26 STK3 STK4 STOML2 SYAP1 SYNCRIP TAB1 TAB3 TADA2B TADA3 TAF15 TAF7 TARBP2 TBCE TBCEL TBL1XR1 TCP1 TCP11L1 TEDC1 TEDC2 TENT2 TERF1 TET2 TFDP1 TFG THAP11 THRAP3 THUMPD1 TMCC3 TMEM30A TMPO TMX3 TOE1 TOM1 TOMM70 TOR1AIP1 TOR1AIP2 TP53 TPP1 TRAF4 TRAF7 TRAK1 TRAK2 TRIM11 TRIM27 TRIM28 TRIP12 TRIT1 TRMT10C TRMT5 TRMT6 TSG101 TSPYL1 TTC31 TTC4 TUBA1A TUBA1B TUBA1C TUBA4A TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBG1 TUFM TXNDC5 U2AF2 UBA1 UBA3 UBA5 UBC UBE2Q1 UBR7 UBXN6 UCHL5 UMPS UPF3B UQCRC1 USP14 UTP18 UTP3 VEZF1 VIM VIPAS39 VPS4A VPS4B VRK1 VRK2 VRK3 WARS1 WBP4 WDR55 WT1 WTAP XIAP XPO1 XRCC4 XRCC6 XRN2 YARS1 YBX1 YBX3 YES1 YJU2B YME1L1 YTHDF2 ZC3H15 ZC3HAV1 ZCCHC3 ZKSCAN4 ZKSCAN8 ZNF124 ZNF207 ZNF277 ZNF385A ZNF397 ZNF436 ZNF460 ZNF48 ZNF622 ZNF70 ZNF703 ZNF768 ZNF787 ZNHIT2 ZPR1 ZRANB2 ZSCAN21
Entrez ID		142	8473
HPRD ID		01435	02222
Ensembl ID		ENSG00000143799	ENSG00000147162
Uniprot IDs		A0A024R3T8 P09874	O15294
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6M3I 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW 7AAA 7AAB 7AAC 7AAD 7CMW 7KK2 7KK3 7KK4 7KK5 7KK6	1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4CDR 4GYW 4GYY 4GZ3 4GZ5 4GZ6 4N39 4N3A 4N3B 4N3C 4XI9 4XIF 5BNW 5C1D 5HGV 5LVV 5LWV 5NPR 5NPS 5VIE 5VIF 6E37 6EOU 6IBO 6MA1 6MA2 6MA3 6MA4 6MA5 6Q4M 6TKA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?