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PRKDC and HNRNPC
Number of citations of the paper that reports this interaction (PubMedID
14704337
)
39
Data Source:
BioGRID
(enzymatic study)
PRKDC
HNRNPC
Description
protein kinase, DNA-activated, catalytic subunit
heterogeneous nuclear ribonucleoprotein C
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Nonhomologous End Joining Complex
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Spliceosomal Complex
Telomerase Holoenzyme Complex
Cytosol
Actin Cytoskeleton
Membrane
Protein-containing Complex
Extracellular Exosome
Catalytic Step 2 Spliceosome
Molecular Function
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Protein Serine Kinase Activity
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Poly(U) RNA Binding
Nucleosomal DNA Binding
Identical Protein Binding
Telomerase RNA Binding
N6-methyladenosine-containing RNA Binding
Biological Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
Negative Regulation Of Immunoglobulin Production
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Response To Activity
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Spleen Development
Thymus Development
Positive Regulation Of Developmental Growth
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Response To Gamma Radiation
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
Chromatin Remodeling
RNA Splicing
Negative Regulation Of Telomere Maintenance Via Telomerase
3'-UTR-mediated MRNA Stabilization
Pathways
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
SUMOylation of RNA binding proteins
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
RHOBTB2 GTPase cycle
RHOBTB1 GTPase cycle
Drugs
Caffeine
SF1126
Diseases
GWAS
Adult body size (
32376654
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Bipolar disorder (
31043756
21738484
)
Height (
31562340
)
Interacting Genes
91 interacting genes:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R3
PRKCD
PTEN
RAD17
RASSF1
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TOP1
TP53
TREX1
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
60 interacting genes:
AP1M1
BARD1
BRCA1
BRCA2
BRIP1
BTRC
CCDC85B
CDKN2A
CSNK1A1
CSNK2A1
CSNK2A2
DHX9
DISC1
DLG4
EPS8
ERG
ESR1
FAS
FXR2
GRB2
HNRNPCL1
HNRNPCL2
IL7R
KHDRBS3
KPNA2
KPNA3
KPNA4
KPNA5
KRAS
LMO2
LMO3
MEOX2
NUFIP2
OGT
PALB2
PAX6
PDGFB
PHKB
PIN1
PJA1
PRKDC
PTBP2
RAD51
RALY
RALYL
RBM41
RBPMS2
SDCBP
SF3B2
SMARCD1
SREK1
SRPK2
SUMO1
SUMO1P1
TRAF3
UBE2I
YWHAE
YWHAQ
ZFYVE26
ZNF581
Entrez ID
5591
3183
HPRD ID
02941
01243
Ensembl ID
ENSG00000253729
ENSG00000092199
Uniprot IDs
P78527
P07910
PDB IDs
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
1TXP
1WF2
2MXY
2MZ1
3LN4
Enriched GO Terms of Interacting Partners
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