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CRKL and SHANK3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
CRKL
SHANK3
Description
CRK like proto-oncogene, adaptor protein
SH3 and multiple ankyrin repeat domains 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Cytosol
Postsynaptic Density
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuron Projection
Dendritic Spine
Neuron Spine
Postsynaptic Membrane
Ciliary Membrane
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Identical Protein Binding
Cadherin Binding
Actin Binding
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SH3 Domain Binding
Synaptic Receptor Adaptor Activity
Ionotropic Glutamate Receptor Binding
Protein Self-association
Scaffold Protein Binding
Biological Process
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
Signal Transduction
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Reelin-mediated Signaling Pathway
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Xenobiotic Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
MAPK Cascade
Synapse Assembly
Learning
Memory
Striatal Medium Spiny Neuron Differentiation
Adult Behavior
Negative Regulation Of Actin Filament Bundle Assembly
Social Behavior
Vocal Learning
Negative Regulation Of Cell Volume
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Brain Morphogenesis
Positive Regulation Of Synapse Structural Plasticity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Vocalization Behavior
Postsynaptic Density Assembly
AMPA Glutamate Receptor Clustering
NMDA Glutamate Receptor Clustering
Guanylate Kinase-associated Protein Clustering
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Glutamate Receptor Signaling Pathway
Regulation Of Long-term Synaptic Depression
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of AMPA Receptor Activity
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Drugs
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Extremely high intelligence (
29520040
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Intelligence (MTAG) (
29326435
)
Mean platelet volume (
32888494
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Platelet count (
32888494
)
Interacting Genes
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CHEK2
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
156 interacting genes:
ABCC2
ABI1
ABI2
ACE2
ACTN2
ADGRL1
AGAP7P
ALDOA
ANKRD35
APP
ARHGAP44
ARPC2
ARPC5L
ATN1
BAIAP2
C1QBP
CA10
CALCOCO1
CAMK2B
CCT3
CENPJ
CEP72
CIBAR1
CLTA
CLU
CNKSR2
COPS5
COPS6
COQ5
CRELD1
CRKL
CSNK1D
CSNK2B
CTTN
CYP51A1
CYTIP
DBNL
DCTN2
DDB1
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DNAJA3
DNM2
EFEMP1
EFEMP2
EID1
ELAVL1
ERI3
FAM13A
FBXO7
FKBP8
FRS3
FRYL
GAPDH
GOT1
GPR162
GPS1
GRB2
GRN
HAGH
HECW1
HGS
HNRNPK
HOMER3
ICA1
IGSF9
ITGBL1
ITSN1
JAG2
KHDRBS1
KIAA0232
LINGO1
LRRC73
LTBP3
LTBP4
LZTS2
LZTS3
MAPK1
MBIP
MBOAT7
MCRS1
MDH2
MEGF10
MEGF11
MEGF6
MIPOL1
MRM3
MT-CO2
MT-ND6
MYO5B
N4BP3
NCK1
NCKIPSD
NEFL
NGRN
NOTCH1
NOTCH2
NOTCH2NLA
NOTCH3
NR1D1
NRBF2
PAX6
PDHB
PFKL
PHF12
PHLDB1
PLEKHA4
PPHLN1
PPP1CC
PPP1R13L
PPP1R9B
PPP2R3B
PRMT2
QSOX1
RBM5
RPL3
RPS6KA1
RTN3
RUNDC3A
SCYL3
SETD2
SH3GL2
SH3GL3
SHANK1
SHARPIN
SIPA1
SLC48A1
SNRPN
SORBS2
SORBS3
SPAG5
SPTAN1
SRSF9
STK32C
SYNGAP1
SYT5
TCF25
TDRD7
TFIP11
THRAP3
TMEM14C
TNIP2
TRAF3
TRIM27
TRIM9
TRIP10
TSG101
TUBA1C
UCHL1
USP8
VIM
VPS18
WWP1
ZCCHC2
Entrez ID
1399
85358
HPRD ID
03596
18979
Ensembl ID
ENSG00000099942
ENSG00000251322
Uniprot IDs
P46109
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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