CR2 and FCER2

Number of citations of the paper that reports this interaction (PubMedID 7515913)
19

Data Source:
HPRD (in vitro)

		CR2	FCER2
Description		complement C3d receptor 2	Fc fragment of IgE receptor II
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	Integrin Binding Protein Binding IgE Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell	Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways		Regulation of Complement cascade	NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			Lumiliximab
Diseases
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)	Blood protein levels ( 30072576 29875488 28240269) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53	5 interacting genes: ATF7 CR2 FYN ITGAX ITGB2
Entrez ID		1380	2208
HPRD ID		00399	01049
Ensembl ID		ENSG00000117322	ENSG00000104921
Uniprot IDs		P20023	K3W4U1 P06734
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED	1HLI 1KJE 1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK
Enriched GO Terms of Interacting Partners?
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