FCER2 and ITGB2

Number of citations of the paper that reports this interaction (PubMedID 7621072)
29

Data Source:
HPRD (in vivo)

		FCER2	ITGB2
Description		Fc fragment of IgE receptor II	integrin subunit beta 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane Cytoplasmic Region Ficolin-1-rich Granule Membrane Extracellular Vesicle
	Molecular Function	Integrin Binding Protein Binding IgE Binding Carbohydrate Binding Metal Ion Binding	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Neuron Death Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways		NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Lumiliximab
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Post bronchodilator FEV1 ( 26634245)	Heel bone mineral density ( 28869591) Lymphocyte counts ( 32888494) Neonatal white matter microstructure ( 33009551)
Interacting Genes		5 interacting genes: ATF7 CR2 FYN ITGAX ITGB2	58 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 CHPF COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ERG ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2
Entrez ID		2208	3689
HPRD ID		01049	02506
Ensembl ID		ENSG00000104921	ENSG00000160255
Uniprot IDs		K3W4U1 P06734	A0A494C0X7 B4E0R1 P05107
PDB IDs		1HLI 1KJE 1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK	1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ
Enriched GO Terms of Interacting Partners?
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