CPE and TRH

Number of citations of the paper that reports this interaction (PubMedID 12270926)
21

Data Source:
HPRD (in vivo)

		CPE	TRH
Description		carboxypeptidase E	thyrotropin releasing hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Extracellular Exosome	Extracellular Region Nucleus Plasma Membrane Secretory Granule
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding	Protein Binding Thyrotropin-releasing Hormone Activity
	Biological Process	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Peptide Metabolic Process Neuropeptide Signaling Pathway Wnt Signaling Pathway Protein Processing Protein Localization To Membrane	Response To Hypoxia Histamine Metabolic Process Signal Transduction Cell-cell Signaling Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior
Pathways		Insulin processing	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Insulin human Insulin pork
Diseases
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alzheimer's disease ( 30636644) Hip index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	8 interacting genes: ARRB2 CD80 CD86 CPE IQCB1 KCNIP4 LCN2 TRHR
Entrez ID		1363	7200
HPRD ID		00272	08944
Ensembl ID		ENSG00000109472	ENSG00000170893
Uniprot IDs		A0A384N679 P16870	P20396
PDB IDs
Enriched GO Terms of Interacting Partners?
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