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BMPR2 and SMURF1
Number of citations of the paper that reports this interaction (PubMedID
31578224
)
0
Data Source:
BioGRID
(pull down, imaging technique)
BMPR2
SMURF1
Description
bone morphogenetic protein receptor type 2
SMAD specific E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleoplasm
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Clathrin-coated Pit
Adherens Junction
Basal Plasma Membrane
Cell Surface
Postsynaptic Density
Apical Plasma Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Spanning Component Of Plasma Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Axon
Neuronal Cell Body
Extracellular Exosome
Molecular Function
Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Protein Binding
ATP Binding
Activin Receptor Activity, Type II
Phosphatase Activator Activity
Growth Factor Binding
Signaling Receptor Activator Activity
BMP Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Metal Ion Binding
BMP Receptor Activity
Transcription Regulator Activator Activity
Protein Tyrosine Kinase Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Phospholipid Binding
Activin Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
Biological Process
Blood Vessel Development
Osteoblast Differentiation
Mesoderm Formation
Maternal Placenta Development
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Remodeling
Chondrocyte Development
Negative Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Development
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Brain Development
Cellular Response To Starvation
Anterior/posterior Pattern Specification
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Lung Blood Pressure
Proteoglycan Biosynthetic Process
Negative Regulation Of Cell Growth
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Activin Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Cardiac Muscle Tissue Development
Positive Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Muscle Cell Differentiation
Limb Development
Endochondral Bone Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Positive Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Endothelial Cell Apoptotic Process
Negative Regulation Of Chondrocyte Proliferation
Semi-lunar Valve Development
Negative Regulation Of DNA Biosynthetic Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Export From Nucleus
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Receptor Catabolic Process
Protein Localization To Cell Surface
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Engulfment Of Target By Autophagosome
Substrate Localization To Autophagosome
Protein Targeting To Vacuole Involved In Autophagy
Protein Localization To Plasma Membrane
Positive Regulation Of Dendrite Extension
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Signaling by BMP
Signaling by BMP
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog 'on' state
Hedgehog 'on' state
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Dibotermin alfa
Fostamatinib
Diseases
GWAS
High light scatter reticulocyte percentage of red cells (
32888494
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
PR interval (
32439900
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
32154731
)
Urate levels (
23263486
)
Facial emotion recognition (sad faces) (
28608620
)
Inflammatory bowel disease (
28067908
23128233
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Ulcerative colitis (
28067908
20228798
)
Interacting Genes
59 interacting genes:
ACTR8
ACVR1
ACVR1B
ARSA
BMP10
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR1B
C4BPA
CASP10
CASP8
CCDC89
CES1
CHRND
CRYAB
CTBP1
DYNLT1
ERBB4
FHL2
FOXL1
FRS3
GDF2
GDF5
GDF6
GDF9
HAT1
HNRNPR
IGFBP2
INHBB
LIMK1
LMX1A
LSM10
LSP1
MAP3K8
MAPK8
MERTK
MOS
NBEA
NOP56
PDZRN3
PMPCA
PPP1CC
PRKCB
RAB11FIP1
RABGGTA
SMURF1
SULT1E1
TDGF1
TGFBR1
TOPBP1
TRIB3
TRPC1
TSR1
TUBB
TUBB4A
TWF1
191 interacting genes:
ADRM1
ANAPC5
ANKRD13A
ANKRD13D
ANKRD50
ANKS4B
ANXA6
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASCC2
ASH2L
ATXN3
AVEN
AXIN1
BMPR2
BTK
BTRC
C9orf78
CALCOCO1
CCDC69
CCM2
CDC40
CDK14
CDKL1
CSNK1D
CSNK2A2
CTNNB1
CTNND1
CTTN
CUEDC1
CUL5
CXXC1
DDX54
DNAJC7
DUSP13
DVL2
ECSIT
ELOF1
ELP3
ENTR1
EPHA1
EPN1
ETV6
FAF2
FBXL15
FBXO3
FBXO30
FCHO1
FES
FGF12
FGR
FKBP3
FSCN1
FZR1
GNG11
GRIPAP1
GRK3
HDGFL3
HIP1
HOMER2
ILRUN
IMPACT
ING2
INPP5B
IRAK2
ITGB1BP1
ITK
JUNB
KRT36
LATS1
LCK
LHX9
LIMS1
LMNA
LONRF3
MAP3K10
MAP3K2
MAP3K3
MAP3K9
MAP4K5
MARK2
MATK
MEPCE
MINDY3
MSN
NAA16
NDFIP2
NEDD8
NEK2
NSD2
ODF2
OTUD6B
OXSR1
PADI4
PAK1
PAK1IP1
PDGFRA
PDLIM7
PICALM
PIP5K1C
PLEKHO1
POLR2A
PRKCA
PRKCG
PRKCI
PRR16
PSMD4
PSME3
PTEN
PWP1
RABEP1
RAD23A
RASD2
RBCK1
RHOA
RHOB
RHPN2
RIOK3
RIPK2
RIT1
RNF11
RNF114
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SCYL1
SENP8
SF3A1
SLAIN2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SPART
SQSTM1
SRSF4
SRSF5
STK31
STK35
STRAP
STUB1
TAB1
TAOK3
TBK1
TLN1
TNIK
TNIP2
TNK2
TNNT1
TOM1
TOM1L2
TPM4
TRAF4
TRIP10
TTC17
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2K
UBE2L3
UBE2M
UBE2V1
UBQLN1
UBQLN2
UBTF
UBXN1
UBXN6
UBXN7
USP45
USP9X
WDR61
WEE1
WFS1
XPO1
ZFAND5
Entrez ID
659
57154
HPRD ID
02880
06902
Ensembl ID
ENSG00000204217
ENSG00000198742
Uniprot IDs
Q13873
Q9HCE7
PDB IDs
2HLQ
3G2F
2LAZ
2LB0
2LB1
2LTX
3PYC
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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