CNR2 and ADAM21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CNR2	ADAM21
Description		cannabinoid receptor 2	ADAM metallopeptidase domain 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perikaryon	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Axon Neuronal Cell Body Sperm Head Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	Response To Amphetamine Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Metabolic Process Sensory Perception Of Pain Leukocyte Chemotaxis Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Activity	Proteolysis Single Fertilization Male Gonad Development
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Interaction With Cumulus Cells And The Zona Pellucida
Drugs		Dronabinol Nabilone Ricinoleic Acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Psychotic experience (distressing) ( 31553412)	Motor coordination ( 34177493) Plasma estrone levels in resected estrogen-receptor positive breast cancer ( 28429243)
Interacting Genes		24 interacting genes: ADAM21 ADIPOQ AGPAT4 CCL4 COMT FXYD3 GNA15 MUC15 NRM PEDS1-UBE2V1 RFT1 SELENOK SLC35E4 SLC39A2 TMEM19 TMEM203 TMEM242 TMEM60 TMEM86A TMPPE TSPO2 YIPF1 YIPF4 YIPF6	2 interacting genes: CNR2 SGTA
Entrez ID		1269	8747
HPRD ID		05444	04755
Ensembl ID		ENSG00000188822	ENSG00000139985
Uniprot IDs		A0A024RAH7 P34972	Q9UKJ8
PDB IDs		2KI9 5ZTY 6KPC 6KPF 6PT0
Enriched GO Terms of Interacting Partners?
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