CNR2 and CCL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CNR2	CCL4
Description		cannabinoid receptor 2	C-C motif chemokine ligand 4
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perikaryon	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process	Response To Amphetamine Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Metabolic Process Sensory Perception Of Pain Leukocyte Chemotaxis Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Activity	Monocyte Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Transcription Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Dronabinol Nabilone Ricinoleic Acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Psychotic experience (distressing) ( 31553412)	Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		24 interacting genes: ADAM21 ADIPOQ AGPAT4 CCL4 COMT FXYD3 GNA15 MUC15 NRM PEDS1-UBE2V1 RFT1 SELENOK SLC35E4 SLC39A2 TMEM19 TMEM203 TMEM242 TMEM60 TMEM86A TMPPE TSPO2 YIPF1 YIPF4 YIPF6	28 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D HRAS MARCHF2 MRM1 PRRG2 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A
Entrez ID		1269	6351
HPRD ID		05444	01657
Ensembl ID		ENSG00000188822	ENSG00000275302
Uniprot IDs		A0A024RAH7 P34972	P13236
PDB IDs		2KI9 5ZTY 6KPC 6KPF 6PT0	1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?
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