CCR5 and CCL8

Number of citations of the paper that reports this interaction (PubMedID 10477718)
79

Data Source:
HPRD (in vivo)

		CCR5	CCL8
Description		C-C motif chemokine receptor 5	C-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Extracellular Space
	Molecular Function	Virus Receptor Activity Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Viral Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471	Pidolic acid
Diseases
GWAS		Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)	Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK	21 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP SDF2 VCAN XCL2
Entrez ID		1234	6355
HPRD ID		03223	03791
Ensembl ID		ENSG00000160791	ENSG00000108700
Uniprot IDs		P51681 Q38L21	P80075
PDB IDs		1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET	1ESR
Enriched GO Terms of Interacting Partners?
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