ADD3 and TRIM8

		ADD3	TRIM8
Description		adducin 3	tripartite motif containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Cytosol Cytoskeleton Plasma Membrane Brush Border Cell-cell Junction Cell Cortex Postsynaptic Density Membrane	Cytosol PML Body
	Molecular Function	Structural Constituent Of Cytoskeleton Calmodulin Binding Actin Filament Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cytoskeleton Organization Barbed-end Actin Filament Capping	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell
Pathways		Miscellaneous transport and binding events RHOD GTPase cycle RHOF GTPase cycle	Interferon gamma signaling
Drugs
Diseases
GWAS		Biliary atresia ( 20460270) Bipolar disorder ( 33263727 31043756 28072414) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) Neutrophil count ( 29403010) Refractive error ( 32231278) White blood cell count ( 29403010)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: AGTR1 ATXN1 CWF19L1 GNG13 HSPB1 OPRM1 PENK PRKCA RPL4 TRIM8 TUBGCP4 UBE2I ZNF76	64 interacting genes: ADD3 BRAP CATSPER1 CBL CCNH DCUN1D1 ESR1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1
Entrez ID		120	81603
HPRD ID		03339	06934
Ensembl ID		ENSG00000148700	ENSG00000171206
Uniprot IDs		Q53FL4 Q59EK1 Q5VU08 Q9UEY8	Q9BZR9
PDB IDs
Enriched GO Terms of Interacting Partners?
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