EXOSC6 and MTREX

Number of citations of the paper that reports this interaction (PubMedID 11719186)
354

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		EXOSC6	MTREX
Description		exosome component 6	Mtr4 exosome RNA helicase
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Exoribonuclease Activity	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process Cellular Response To DNA Damage Stimulus SnRNA Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	15 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 XRN1
Entrez ID		118460	23517
HPRD ID		12107	13777
Ensembl ID		ENSG00000223496	ENSG00000039123
Uniprot IDs		Q5RKV6	P42285 Q3MHC9
PDB IDs		2NN6 6D6Q 6D6R 6H25	6C90 6D6Q 6D6R 6IEG 6IEH 6RO1
Enriched GO Terms of Interacting Partners?
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