MTREX and EXOSC2

Number of citations of the paper that reports this interaction (PubMedID 11719186)
354

Data Source:
HPRD (in vivo)

		MTREX	EXOSC2
Description		Mtr4 exosome RNA helicase	exosome component 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process Cellular Response To DNA Damage Stimulus SnRNA Catabolic Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 XRN1	29 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MRPL48 MTREX MTX2 NCS1 NELFB PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 VCAM1 ZNF408
Entrez ID		23517	23404
HPRD ID		13777	03758
Ensembl ID		ENSG00000039123	ENSG00000130713
Uniprot IDs		P42285 Q3MHC9	B3KQW2 Q13868
PDB IDs		6C90 6D6Q 6D6R 6IEG 6IEH 6RO1	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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