PRLR and NEK3

Number of citations of the paper that reports this interaction (PubMedID 15618286)
30

Data Source:
HPRD (in vivo)

		PRLR	NEK3
Description		prolactin receptor	NIMA related kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex	Nucleus Cytoplasm Axon
	Molecular Function	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Prolactin Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Prolactin Signaling Pathway Oncostatin-M-mediated Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Mitotic Cell Cycle Protein Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Tubulin Deacetylation
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatotropin	Fostamatinib
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		22 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 ICAM3 INSIG2 JAK2 MFGE8 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2
Entrez ID		5618	4752
HPRD ID		01457	04954
Ensembl ID		ENSG00000113494	ENSG00000136098
Uniprot IDs		P16471	P51956 Q6ZN64
PDB IDs		1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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