FCRL3 and IGFBP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FCRL3	IGFBP5
Description		Fc receptor like 3	insulin like growth factor binding protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Kinase Binding Phosphatase Binding Protein Phosphatase Binding Protein Tyrosine Kinase Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Regulation Of Calcium Ion Import Positive Regulation Of Protein Serine/threonine Phosphatase Activity	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Graves' disease ( 21841780) IgA nephropathy ( 32912934 26028593) Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes ( 21829393) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758)	Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Visceral fat ( 22589738)
Interacting Genes		12 interacting genes: AGPAT4 CMTM5 FCRL1 IGFBP5 MS4A1 PTPN11 PTPN6 SLC2A5 SLC30A3 STATH SYK ZAP70	93 interacting genes: ABHD4 ADAM12 AHNAK2 AMIGO1 ANKS6 APH1A AQP2 AQP6 AQP9 ASGR1 BAG6 BSND CD53 CERS4 CHODL CLDN2 CLDN20 CLDN6 CLDN7 CLDN9 CLEC17A CREB3 CSDE1 CXCR1 ELOVL5 ERGIC3 F2 FAM209A FCRL3 FHL1 FHL2 FN1 FNDC9 GJA5 GJA8 GJB3 GJB5 GOLM1 GPR151 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HSD17B13 IGF1 IGF2 IGFALS KCNK5 KIAA2013 KPNB1 LAPTM4B LAYN LDLRAD1 LHFPL1 LMNA LTBP1 MFF MFSD5 MRPS18B MS4A3 MS4A7 NCAPH2 PAPPA2 PDZK1IP1 PNO1 PROKR2 RASSF1 RHCG SERPINE1 SLC10A6 SLC13A4 SLC38A1 SLC41A2 SLC41A3 SPAG4 SPP1 SYNE4 TF THAP4 THBS1 TLCD4 TMEM106A TMEM106C TMEM179B TMEM237 TMEM45A TMEM52B TMPRSS2 TMX2 TSPAN12 TSPO2 VTN
Entrez ID		115352	3488
HPRD ID		07352	00901
Ensembl ID		ENSG00000160856	ENSG00000115461
Uniprot IDs		Q96P31	P24593
PDB IDs			1BOE 1H59
Enriched GO Terms of Interacting Partners?
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