RHPN1 and CNKSR1

Number of citations of the paper that reports this interaction (PubMedID 14749388)
26

Data Source:
HPRD (in vitro, in vivo)

		RHPN1	CNKSR1
Description		rhophilin Rho GTPase binding protein 1	connector enhancer of kinase suppressor of Ras 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS			Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		17 interacting genes: CALCOCO2 CEP70 CNKSR1 EFEMP2 GOLGA2 GPRASP2 HAP1 KRT15 KRT31 LZTS1 MTUS2 RHOA ROPN1 TRIM27 TRIM37 TRIM55 TRIM63	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		114822	10256
HPRD ID		17973	11937
Ensembl ID		ENSG00000158106	ENSG00000142675
Uniprot IDs		Q8TCX5	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs			1WWV
Enriched GO Terms of Interacting Partners?
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