SYNPO and G3BP1

		SYNPO	G3BP1
Description		synaptopodin	G3BP stress granule assembly factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytosol Bicellular Tight Junction Postsynaptic Density Actin Cytoskeleton Z Disc Dendritic Spine Perikaryon Spine Apparatus	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex
	Molecular Function	Actin Binding Protein Binding	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding ATP Hydrolysis Activity DNA/RNA Helicase Activity
	Biological Process	Positive Regulation Of Actin Filament Bundle Assembly Modification Of Dendritic Spine Spine Apparatus Assembly	Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401)	Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: CDC5L G3BP1 MAGI1 NCK1 NCK2 NDST1 NONO NUFIP2 SGF29 YWHAG YWHAZ	17 interacting genes: APP CSK DNAH1 DTX1 EPHA8 FBXO25 HAND1 HMGXB3 IL7R LCK LINC01554 OGT PIN1 PPIA RASA1 SYNPO USP10
Entrez ID		11346	10146
HPRD ID		12179	06569
Ensembl ID		ENSG00000171992	ENSG00000145907
Uniprot IDs		Q8N3V7	Q13283 Q5U0Q1 Q6ZP53
PDB IDs			3Q90 4FCJ 4FCM 4IIA 5FW5
Enriched GO Terms of Interacting Partners?
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