USP18 and ISG15

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USP18	ISG15
Description		ubiquitin specific peptidase 18	ISG15 ubiquitin like modifier
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Small Ribosomal Subunit
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding ISG15-specific Protease Activity	Structural Constituent Of Ribosome Integrin Binding Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Regulation Of Inflammatory Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway	Integrin-mediated Signaling Pathway Response To Virus Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Interferon-gamma Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion
Pathways		ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 33272962)	Blood protein levels ( 30072576 29875488)
Interacting Genes		6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17	5 interacting genes: HDAC6 HIF1A UBA7 USP18 USP21
Entrez ID		11274	9636
HPRD ID		06136	00958
Ensembl ID		ENSG00000184979	ENSG00000187608
Uniprot IDs		Q9UMW8	P05161
PDB IDs			1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9
Enriched GO Terms of Interacting Partners?
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