HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
ISG15 and HIF1A
Number of citations of the paper that reports this interaction (PubMedID
24056783
)
11
Data Source:
BioGRID
(pull down)
ISG15
HIF1A
Description
ISG15 ubiquitin like modifier
hypoxia inducible factor 1 subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytosolic Small Ribosomal Subunit
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Molecular Function
Structural Constituent Of Ribosome
Integrin Binding
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Nuclear Receptor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
E-box Binding
Biological Process
Integrin-mediated Signaling Pathway
Response To Virus
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Positive Regulation Of Bone Mineralization
Negative Regulation Of Protein Ubiquitination
ISG15-protein Conjugation
Positive Regulation Of Protein Oligomerization
Regulation Of Interferon-gamma Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Response To Type I Interferon
Defense Response To Bacterium
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Erythrocyte Differentiation
Defense Response To Virus
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Protein Localization To Mitochondrion
Response To Reactive Oxygen Species
Angiogenesis
Response To Hypoxia
Cellular Glucose Homeostasis
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Signal Transduction
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of TOR Signaling
Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Embryonic Hemopoiesis
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Hemoglobin Biosynthetic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Digestive Tract Morphogenesis
Positive Regulation Of Nitric-oxide Synthase Activity
Cartilage Development
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Autophagy Of Mitochondrion
Regulation Of Aerobic Respiration
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Interferon alpha/beta signaling
Negative regulators of DDX58/IFIH1 signaling
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Circadian Clock
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
STAT3 nuclear events downstream of ALK signaling
Drugs
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Interacting Genes
5 interacting genes:
HDAC6
HIF1A
UBA7
USP18
USP21
127 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ARNTL
ATM
AURKA
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FBXO8
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SNHG11
SP1
SSX4
STAT3
STK11
STUB1
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
USP19
USP20
USP28
USP7
VEGFA
VHL
VHLL
ZC3H12A
Entrez ID
9636
3091
HPRD ID
00958
04517
Ensembl ID
ENSG00000187608
ENSG00000100644
Uniprot IDs
P05161
D0VY79
Q16665
PDB IDs
1Z2M
2HJ8
3PHX
3PSE
3R66
3RT3
3SDL
5TL6
5W8T
5W8U
6BI8
6FFA
6XA9
1D7G
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
6YW3
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?