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ZHX1 and PSMD11
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
888
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ZHX1
PSMD11
Description
zinc fingers and homeoboxes 1
proteasome 26S subunit, non-ATPase 11
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Protein Heterodimerization Activity
Structural Molecule Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Proteasome Assembly
Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Schizophrenia (
33169155
)
Interacting Genes
54 interacting genes:
AKR1C3
AKT1
ATXN1
BARD1
BCL2L1
BHLHE40
BID
CHD3
CREB1
CREBBP
CSNK2A1
DDX39B
DLST
DYNLL1
EFNA2
ELL
GADD45A
GNG11
GSK3B
HSPE1
IDH1
LAMA4
LYAR
MPHOSPH6
NACA
NFYA
PAFAH1B3
PEX14
PIAS4
PIGC
PNP
PRPF40A
PSMD11
SAT1
SERPINB9
SUMO1
SUMO2
TAL1
TALDO1
TARDBP
TERF1
TNFRSF10C
TOLLIP
TP53
UBC
UTP3
VIM
WDR33
ZBED1
ZHX2
ZHX3
ZMYND11
ZNF33B
ZYX
39 interacting genes:
APP
BRD7
CCDC90B
CCSER2
CDC42
COPS2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRKAB2
PRKACA
PRMT6
PSMC5
PSMD6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
Entrez ID
11244
5717
HPRD ID
10379
05119
Ensembl ID
ENSG00000165156
ENSG00000108671
Uniprot IDs
A0A024R9F1
Q9UKY1
O00231
PDB IDs
2ECB
2GHF
2LY9
3NAR
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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