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PSMD11 and RBM48
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
888
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMD11
RBM48
Description
proteasome 26S subunit, non-ATPase 11
RNA binding motif protein 48
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Nucleoplasm
Molecular Function
Structural Molecule Activity
Protein Binding
RNA Binding
Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Proteasome Assembly
Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Schizophrenia (
33169155
)
Hip circumference adjusted for BMI (
34021172
)
Idiopathic dilated cardiomyopathy (
29495422
)
Interacting Genes
39 interacting genes:
APP
BRD7
CCDC90B
CCSER2
CDC42
COPS2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRKAB2
PRKACA
PRMT6
PSMC5
PSMD6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
73 interacting genes:
AMOT
ANXA7
APLP1
ARMC7
ATPAF2
BID
BTBD2
C11orf49
CCDC106
CCDC57
CDK5RAP2
CDKN1A
CDKN2C
COX17
COX5B
EIF1AD
ERH
FAM118B
FAM90A1
FXYD6
GADD45G
GLYAT
GSE1
GSTO1
GYS1
HSF2BP
HSPB1
HSPB3
ID2
JMY
KIF9
KPNA2
MAFG
MAP7D1
MLH1
MLLT3
MNAT1
MPHOSPH6
NTAQ1
NUDT21
OSGEP
PAFAH1B3
PCDHA4
PIBF1
PNP
POLR1C
PPP1R8
PRG2
PRKAB2
PSMD11
RAB27A
RAD51D
RFC5
RPA2
S100Z
SAT1
SCNM1
SERPINB9
SH3GL3
SMN1
SPRED2
SULT1E1
TAF9
TBC1D22B
TEKT4
TK1
TNFSF10
TRDMT1
TRIB3
TSR2
VIM
WDR33
ZNF24
Entrez ID
5717
84060
HPRD ID
05119
13173
Ensembl ID
ENSG00000108671
ENSG00000127993
Uniprot IDs
O00231
Q5RL73
PDB IDs
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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