ZWINT and MAFB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ZWINT	MAFB
Description		ZW10 interacting kinetochore protein	MAF bZIP transcription factor B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Cytoplasm Cytosol Nuclear Body Dendrite	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding Protein N-terminus Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Checkpoint Signaling Mitotic Spindle Assembly Checkpoint Signaling Cell Division Establishment Of Localization In Cell	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Segment Specification Sensory Organ Development Respiratory Gaseous Exchange By Respiratory System Rhombomere 5 Development Rhombomere 6 Development Abducens Nerve Formation T Cell Differentiation In Thymus Brain Segmentation Inner Ear Morphogenesis Fat Cell Differentiation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Development
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Cognitive function in longevity ( 33607172) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)	Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 30172743) Cholesterol, total ( 24097068 25961943 20686565) Cleft lip with or without cleft palate ( 28054174) Cognitive decline rate in late mild cognitive impairment ( 26252872) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Dupuytren's disease ( 28886342 21732829) Height ( 25282103) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 24097068 19060906 25961943 20686565) LDL cholesterol levels ( 32203549 28334899) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Metabolite levels (lipoprotein measures) ( 27005778) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Orofacial clefts ( 28054174) Paneth cell defects in Crohn's disease ( 28352666) Plasma parathyroid hormone levels ( 30134803) QT interval (ambient particulate matter interaction) ( 28749367) Red blood cell count ( 32888494) Response to TNF antagonist treatment ( 18615156) Serum alkaline phosphatase levels ( 33547301) Serum total protein level ( 29403010) Spleen volume ( 34128465) Total body bone mineral density ( 29304378) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10	12 interacting genes: ATF4 BACH1 FOS FOSL1 HOXD12 JUN KRTAP4-2 MAF STK4 ZDHHC2 ZFP64 ZWINT
Entrez ID		11130	9935
HPRD ID		18366	07129
Ensembl ID		ENSG00000122952	ENSG00000204103
Uniprot IDs		O95229	Q9Y5Q3
PDB IDs
Enriched GO Terms of Interacting Partners?
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