PRDM5 and FBXO44

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRDM5	FBXO44
Description		PR/SET domain 5	F-box protein 44
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Regulation Of Gene Expression Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Cellular Response To Leukemia Inhibitory Factor	Glycoprotein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		F-cell distribution in sickle cell anaemia ( 21326311) Fasting plasma glucose ( 17903298) Hemoglobin levels ( 33491795) Loneliness (multivariate analysis) ( 27629369) Monobrow thickness ( 26926045) Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Sensorimotor dexterity ( 31596458)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		7 interacting genes: ADPRS CLCN1 FAAP20 FBXO44 RASD1 TYK2 VIPR1	13 interacting genes: BLOC1S1 BORCS6 BRCA1 C11orf45 HSF2BP ISY1-RAB43 MEOX2 NPHP4 PRDM5 SERTAD3 SKP1 SPG21 UBC
Entrez ID		11107	93611
HPRD ID		17902	16445
Ensembl ID		ENSG00000138738	ENSG00000132879
Uniprot IDs		Q9NQX1	A0A024R4F9 A0A024R4J6 B7Z1P2 Q9H4M3
PDB IDs			3WSO 5B4N
Enriched GO Terms of Interacting Partners?
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