PIM2 and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
26

Data Source:
BioGRID (two hybrid)

		PIM2	TRIM14
Description		Pim-2 proto-oncogene, serine/threonine kinase	tripartite motif containing 14
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GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of Autophagy Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS			Multiple sclerosis ( 31604244)
Interacting Genes		16 interacting genes: ATXN1 BAD CUTC DAPK1 FBH1 FBP1 FBXO7 GSK3B HNRNPH3 HSF1 IKBKG NDUFB8 RPL21 SOCS1 TRIM14 ZNF821	85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		11040	9830
HPRD ID		02244	05948
Ensembl ID		ENSG00000102096	ENSG00000106785
Uniprot IDs		A0A024QYW7 Q9P1W9	A0A024R165 Q14142
PDB IDs		2IWI 4X7Q	6JBM
Enriched GO Terms of Interacting Partners?
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