STIP1 and MAP3K8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		STIP1	MAP3K8
Description		stress induced phosphoprotein 1	mitogen-activated protein kinase kinase kinase 8
Image
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Cytosol Protein-containing Complex Chaperone Complex Dynein Axonemal Particle	Cytosol
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Hsp70 Protein Binding Chaperone Binding Hsp90 Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Cellular Response To Interleukin-7	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RND1 GTPase cycle	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Copper
Diseases
GWAS		Attention deficit hyperactivity disorder ( 21784300) Body shape index ( 34021172) Crohn's disease ( 28067908) Fruit consumption ( 32066663) Monocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		25 interacting genes: ACD ACVR1 AIP APP CDC37 CLCN1 CLK1 EGFR ERBB2 FKBP4 FKBP5 HSP90AA1 HSPA14 HSPA1A HSPA1B HSPA8 LMO2 MAP3K8 OGT POT1 PRNP PTGES3 SUMO2 SUMO4 YIF1A	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		10963	1326
HPRD ID		05454	01863
Ensembl ID		ENSG00000168439	ENSG00000107968
Uniprot IDs		P31948 V9HW72	P41279 Q6FG25
PDB IDs		1ELR 1ELW 2LNI 2NC9 3ESK 3FWV	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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