MTHFD2 and NAGK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		MTHFD2	NAGK
Description		methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	N-acetylglucosamine kinase
Image
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Matrix	Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding Phosphate Ion Binding	Protein Binding ATP Binding N-acetylglucosamine Kinase Activity
	Biological Process	Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process	N-acetylglucosamine Metabolic Process N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process Carbohydrate Phosphorylation
Pathways		Metabolism of folate and pterines	Synthesis of UDP-N-acetyl-glucosamine
Drugs		Tetrahydrofolic acid NADH	N-Acetylglucosamine
Diseases
GWAS			Blood protein levels ( 30072576 29875488 28240269) Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		4 interacting genes: DAPK1 LMNA NAGK PTEN	34 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DYNC1I1 ELP4 GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82
Entrez ID		10797	55577
HPRD ID		05351	08441
Ensembl ID		ENSG00000065911	ENSG00000124357
Uniprot IDs		P13995	A0A384N6G7 C9JEV6 Q9UJ70
PDB IDs		1ZN4 5TC4 6JIB 6JID 6KG2	2CH5 2CH6
Enriched GO Terms of Interacting Partners?
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