SIX2 and CLIP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SIX2	CLIP4
Description		SIX homeobox 2	CAP-Gly domain containing linker protein family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Cytoplasm Microtubule Plus-end Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Microtubule Plus-end Binding
	Biological Process	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Population Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation	Cytoplasmic Microtubule Organization
Pathways
Drugs
Diseases
GWAS		Blood sugar levels ( 29403010) Clozapine-induced myocarditis in schizophrenia ( 32066683) Fasting blood glucose ( 33842983 29621232) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Refractive error ( 32231278) Retinal arteriole-to-venule ratio ( 31597446)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: APP CDKN2A CLIP4 EYA1 EYA3 TLE1 TLE3 TLE5	37 interacting genes: APP CDK5RAP2 CLIP1 CMYA5 DCAF6 DES DST GLP1R HSF2BP JAKMIP2 KIF1B KIFC3 LZTS2 MAGEA12 MAP7 MAP7D1 MEOX2 MYBPC1 MYH3 PCARE PDE4DIP PEG10 SIX2 SON SPDYA TACC3 TAF1 TNNT1 TNNT3 TOGARAM2 TPM1 TRIM32 TRIP13 TRMT61B TTN TULP3 ZNF114
Entrez ID		10736	79745
HPRD ID		05408	08634
Ensembl ID		ENSG00000170577	ENSG00000115295
Uniprot IDs		Q8TBA2 Q9NPC8	A8K6D0 B7Z936 Q8N3C7
PDB IDs			2Z0W
Enriched GO Terms of Interacting Partners?
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