SIX2 and EYA3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SIX2	EYA3
Description		SIX homeobox 2	EYA transcriptional coactivator and phosphatase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Population Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation	Double-strand Break Repair Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Blood sugar levels ( 29403010) Clozapine-induced myocarditis in schizophrenia ( 32066683) Fasting blood glucose ( 33842983 29621232) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Refractive error ( 32231278) Retinal arteriole-to-venule ratio ( 31597446)	Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)
Interacting Genes		8 interacting genes: APP CDKN2A CLIP4 EYA1 EYA3 TLE1 TLE3 TLE5	7 interacting genes: CRK DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		10736	2140
HPRD ID		05408	09042
Ensembl ID		ENSG00000170577	ENSG00000158161
Uniprot IDs		Q8TBA2 Q9NPC8	Q99504
PDB IDs
Enriched GO Terms of Interacting Partners?
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