CFL2 and SSH1

Number of citations of the paper that reports this interaction (PubMedID 12684437)
79

Data Source:
HPRD (in vivo)

		CFL2	SSH1
Description		cofilin 2	slingshot protein phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cleavage Furrow Synapse
	Molecular Function	Protein Binding Actin Filament Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Skeletal Muscle Tissue Development Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Cell Motility Actin Filament Severing	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Dephosphorylation Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Atrial fibrillation ( 30061737 29892015) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (alanine transaminase) ( 33972514) Takayasu arteritis ( 33308445)	Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252) Platelet count ( 32888494)
Interacting Genes		15 interacting genes: ACTB ACTG1 CAP2 CFL1 DSTN LAIR1 LIMK1 POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I ZYG11B	6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN
Entrez ID		1073	54434
HPRD ID		03262	09486
Ensembl ID		ENSG00000165410	ENSG00000084112
Uniprot IDs		Q549N0 Q9Y281	Q8WYL5
PDB IDs
Enriched GO Terms of Interacting Partners?
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