PTGES3 and CASP7

Number of citations of the paper that reports this interaction (PubMedID 18723680)
180

Data Source:
BioGRID (enzymatic study, enzymatic study)

		PTGES3	CASP7
Description		prostaglandin E synthase 3	caspase 7
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytosol Protein-containing Complex Chaperone Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Glycogen Biosynthetic Process Protein Folding Telomere Maintenance Via Telomerase Signal Transduction Cell Population Proliferation Cyclooxygenase Pathway Positive Regulation Of Phosphorylation Glucocorticoid Receptor Signaling Pathway Skin Development Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity Lung Saccule Development Telomerase Holoenzyme Complex Assembly	Proteolysis Apoptotic Process Heart Development Aging Response To UV Protein Processing Striated Muscle Cell Differentiation Neuron Apoptotic Process Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Acetaminophen Grn163l Copper	Fica Emricasan Incadronic acid
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)
Interacting Genes		29 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPB1 NR3C1 NR3C2 STIP1 SURF1 TERT THRA	63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SLC30A9 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		10728	840
HPRD ID		06138	03457
Ensembl ID		ENSG00000110958	ENSG00000165806
Uniprot IDs		A0A024RB32 A0A087WYT3 B3KUY2 Q15185	A0A0A0MRL7 B4DWA2 P55210
PDB IDs		1EJF 1LG0	1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z
Enriched GO Terms of Interacting Partners?
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