PTGES3

Description		prostaglandin E synthase 3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytosol Protein-containing Complex Chaperone Complex
	Molecular Function	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Glycogen Biosynthetic Process Protein Folding Telomere Maintenance Via Telomerase Signal Transduction Cell Population Proliferation Cyclooxygenase Pathway Positive Regulation Of Phosphorylation Glucocorticoid Receptor Signaling Pathway Skin Development Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity Lung Saccule Development Telomerase Holoenzyme Complex Assembly
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs		Acetaminophen Grn163l Copper
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		29 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPB1 NR3C1 NR3C2 STIP1 SURF1 TERT THRA
Entrez ID		10728
HPRD ID		06138
Ensembl ID		ENSG00000110958
Uniprot IDs		A0A024RB32 A0A087WYT3 B3KUY2 Q15185
PDB IDs		1EJF 1LG0
Enriched GO Terms of Interacting Partners?
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