CCT4 and CCT2

Number of citations of the paper that reports this interaction (PubMedID 22939629)
326

Data Source:
BioGRID (biochemical, two hybrid, proximity labelling technology, affinity chromatography technology, biochemical)

		CCT4	CCT2
Description		chaperonin containing TCP1 subunit 4	chaperonin containing TCP1 subunit 2
Image
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Nucleoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Projection Cell Body Extracellular Exosome	Zona Pellucida Receptor Complex Extracellular Region Cytosol Chaperonin-containing T-complex Microtubule Azurophil Granule Lumen Cell Body Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Chaperone Mediated Protein Folding Independent Of Cofactor Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Plasma free amino acid levels ( 30659259)	Height ( 18391951) Logical memory (delayed recall) in normal cognition ( 29274321) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		17 interacting genes: ACTA1 ACTA2 ACTB CCNE1 CCNH CCT2 CFAP52 COP1 LINC01554 MTDH OGT PRPF40A PTEN RPS6KA1 SUMO2 VRK2 WDPCP	25 interacting genes: ACTA1 ACTB CCT4 EEF2 ERLIN2 ESR1 FCHSD2 GLI1 HSP90AB1 HSP90B1 LINC01554 NPSR1 OGT PRPF40A PSMC6 PSMD2 PTEN RPS3 SUMO2 SUMO4 TUBA1B VAV2 VRK2 YWHAG ZNRD2
Entrez ID		10575	10576
HPRD ID		05506	06895
Ensembl ID		ENSG00000115484	ENSG00000166226
Uniprot IDs		P50991	P78371 V9HW96
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP
Enriched GO Terms of Interacting Partners?
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