CCT4 and WDPCP

		CCT4	WDPCP
Description		chaperonin containing TCP1 subunit 4	WD repeat containing planar cell polarity effector
Image			No pdb structure
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Nucleoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Projection Cell Body Extracellular Exosome	Plasma Membrane Axoneme Cell Cortex Apical Plasma Membrane Axonemal Basal Plate
	Molecular Function	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Septin Cytoskeleton Organization Regulation Of Protein Localization Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Glomerular Visceral Epithelial Cell Migration Regulation Of Ruffle Assembly Regulation Of Establishment Of Cell Polarity
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Plasma free amino acid levels ( 30659259)	Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		17 interacting genes: ACTA1 ACTA2 ACTB CCNE1 CCNH CCT2 CFAP52 COP1 LINC01554 MTDH OGT PRPF40A PTEN RPS6KA1 SUMO2 VRK2 WDPCP	9 interacting genes: AHSA2P B3GNT2 CCT4 COMMD1 EHBP1 FAM161A PNPT1 PPP3R1 USP34
Entrez ID		10575	51057
HPRD ID		05506	14228
Ensembl ID		ENSG00000115484	ENSG00000143951
Uniprot IDs		P50991	O95876
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP
Enriched GO Terms of Interacting Partners?
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