TM9SF1 and P2RX7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TM9SF1	P2RX7
Description		transmembrane 9 superfamily member 1	purinergic receptor P2X 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Lysosomal Membrane Membrane Integral Component Of Membrane Cytoplasmic Vesicle	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Bleb Postsynapse
	Molecular Function		Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Autophagy Protein Localization To Membrane	Regulation Of Sodium Ion Transport Response To Ischemia Cell Surface Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Interleukin-1 Beta Production Response To ATP Positive Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Purinergic Nucleotide Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Pore Complex Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To ATP Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Bleb Assembly Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Pathways			Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs			Promethazine
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Interacting Genes		5 interacting genes: MTNR1A P2RX7 RNASEH1 TCOF1 ZBTB14	20 interacting genes: ACTB CASK CSF2 CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 PTPN11 SVIL TM9SF1 TRIM27 ZNF655
Entrez ID		10548	5027
HPRD ID		09987	03977
Ensembl ID		ENSG00000100926	ENSG00000089041
Uniprot IDs		B4E3A9 G3V1B9 O15321	Q99572
PDB IDs
Enriched GO Terms of Interacting Partners?
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