P2RX7 and CASK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		P2RX7	CASK
Description		purinergic receptor P2X 7	calcium/calmodulin dependent serine protein kinase
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Bleb Postsynapse	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Vesicle Presynaptic Membrane Ciliary Membrane Schaffer Collateral - CA1 Synapse
	Molecular Function	Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Sodium Ion Transport Response To Ischemia Cell Surface Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Interleukin-1 Beta Production Response To ATP Positive Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Purinergic Nucleotide Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Pore Complex Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To ATP Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Bleb Assembly Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Promethazine	Formic acid Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Interacting Genes		20 interacting genes: ACTB CASK CSF2 CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 PTPN11 SVIL TM9SF1 TRIM27 ZNF655	87 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L C20orf85 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WHRN WNT7B YWHAE
Entrez ID		5027	8573
HPRD ID		03977	02164
Ensembl ID		ENSG00000089041	ENSG00000147044
Uniprot IDs		Q99572	A0A2R8Y6F8 A0A2R8YE77 A0A7I2RJN6 O14936
PDB IDs			1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH
Enriched GO Terms of Interacting Partners?
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