CORO2B and ECSIT

		CORO2B	ECSIT
Description		coronin 2B	ECSIT signaling integrator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Actin Cytoskeleton Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Actin Binding Protein Binding Vinculin Binding Actin Filament Binding Talin Binding	Protein Binding
	Biological Process	Regulation Of Glomerular Filtration Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Focal Adhesion Assembly Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Response To Stress Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization	Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways			MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) PR interval ( 32439900) Systolic blood pressure ( 26969751)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		6 interacting genes: ACTA1 APPBP2 ECSIT NMB TSC22D1 VCL	61 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CNN1 CORO2B CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MARCHF2 MAST1 MKRN3 MRPL4 NDUFA13 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		10391	51295
HPRD ID		05416	12225
Ensembl ID		ENSG00000103647	ENSG00000130159
Uniprot IDs		Q9UQ03	Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?
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