FSTL3 and ADAM12

Number of citations of the paper that reports this interaction (PubMedID 15574124)
8

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		FSTL3	ADAM12
Description		follistatin like 3	ADAM metallopeptidase domain 12
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Neuron Projection Terminus	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Protein Binding Activin Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Adrenal Gland Development Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis
Pathways		Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Signaling by EGFR Invadopodia formation
Drugs
Diseases
GWAS		Nickel levels ( 26025379)	Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4	42 interacting genes: ACTN2 ADAMTSL4 CYSRT1 DOCK1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D TUBGCP2 YES1
Entrez ID		10272	8038
HPRD ID		05632	04092
Ensembl ID		ENSG00000070404	ENSG00000148848
Uniprot IDs		A0A024R1Y8 O95633	A8K6G4 O43184 U5NE98
PDB IDs		2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?
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