FSTL3 and MSTN

Number of citations of the paper that reports this interaction (PubMedID 12194980)
142

Data Source:
HPRD (in vivo, in vitro)

		FSTL3	MSTN
Description		follistatin like 3	myostatin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Neuron Projection Terminus	Extracellular Space Cytoplasm
	Molecular Function	Fibronectin Binding Protein Binding Activin Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Adrenal Gland Development Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Negative Regulation Of Kinase Activity Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways		Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	FOXO-mediated transcription of cell cycle genes
Drugs			MYO-029
Diseases
GWAS		Nickel levels ( 26025379)	Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)
Interacting Genes		5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4	7 interacting genes: ACVR2B APP FSTL3 MFSD6 SGTA TCAP WFIKKN2
Entrez ID		10272	2660
HPRD ID		05632	03474
Ensembl ID		ENSG00000070404	ENSG00000138379
Uniprot IDs		A0A024R1Y8 O95633	O14793 Q53S46
PDB IDs		2KCX 3B4V 3SEK	5F3B 5F3H 5NTU 5NXS 6UMX
Enriched GO Terms of Interacting Partners?
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