ADAM12 and DOCK1

		ADAM12	DOCK1
Description		ADAM metallopeptidase domain 12	dedicator of cytokinesis 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Epithelial Cell Migration Regulation Of Catalytic Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Signaling by EGFR Invadopodia formation	Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)	Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		42 interacting genes: ACTN2 ADAMTSL4 CYSRT1 DOCK1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D TUBGCP2 YES1	18 interacting genes: ADAM12 BCAR1 C10orf90 CLRN3 CRK CYTH2 ELMO1 ELMO2 MMP21 NCK2 PRKACA PSAT1 RAC1 RHOG STX16 TAMALIN TLK2 WASF2
Entrez ID		8038	1793
HPRD ID		04092	03240
Ensembl ID		ENSG00000148848	ENSG00000150760
Uniprot IDs		A8K6G4 O43184 U5NE98	A0A2X0U2H5 B2RUU3 Q14185
PDB IDs			3L4C
Enriched GO Terms of Interacting Partners?
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