HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
CDK5 and PTPN2
Number of citations of the paper that reports this interaction (PubMedID
15030318
)
5
Data Source:
HPRD
(in vitro, in vivo)
CDK5
PTPN2
Description
cyclin dependent kinase 5
protein tyrosine phosphatase non-receptor type 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Perikaryon
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Molecular Function
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Protein Kinase Binding
Acetylcholine Receptor Activator Activity
ErbB-3 Class Receptor Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
Protein Serine Kinase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
Protein Kinase Binding
Syntaxin Binding
Receptor Tyrosine Kinase Binding
STAT Family Protein Binding
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Protein Phosphorylation
Intracellular Protein Transport
Nucleocytoplasmic Transport
Mitochondrion Organization
Cell-matrix Adhesion
Chemical Synaptic Transmission
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Visual Learning
Response To Wounding
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Phosphorylation
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Corpus Callosum Development
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Cortical Actin Cytoskeleton Organization
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Positive Regulation Of Protein Binding
Receptor Catabolic Process
Positive Regulation Of Glial Cell Apoptotic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Serine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Autophosphorylation
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Positive Regulation Of Protein Targeting To Membrane
Synapse Pruning
Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Negative Regulation Of Neuron Death
Positive Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of Protein Localization To Plasma Membrane
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Chemotaxis
Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Factors involved in megakaryocyte development and platelet production
Negative regulation of MET activity
Interleukin-37 signaling
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Alopecia areata (
25608926
)
Autoimmune thyroid disease (
32581359
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index (
25673413
)
C-reactive protein levels (
30388399
21300955
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
25489960
28067908
17554261
17554300
21102463
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Esophageal cancer (squamous cell) (
22960999
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
28067908
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lead levels in blood (
25820613
)
Lymphocyte counts (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Psoriasis (
28537254
)
Red blood cell count (
32888494
)
Rheumatoid arthritis (
30423114
22446963
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Selective IgA deficiency (
27723758
)
Type 1 diabetes (
21829393
25751624
19430480
17554260
18978792
)
Interacting Genes
82 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CCNI
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
CTNNB1
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PRKN
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SPDYE4
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
29 interacting genes:
CDK1
CDK2
CDK5
COLEC12
EGFR
FAM220A
FKBP4
GHR
GJB1
HMGB1
INSR
ITGA1
JAK1
JAK3
KPNB1
MRPS7
OCLN
PDGFRB
PTMA
SHC1
SRC
SRPK1
STAT1
STAT3
STAT5A
STAT5B
STX17
UBC
ZBTB14
Entrez ID
1020
5771
HPRD ID
00449
06768
Ensembl ID
ENSG00000164885
ENSG00000175354
Uniprot IDs
A0A090N7W4
A0A0S2Z355
Q00535
A8K3N4
D3DUJ3
K7EQG9
P17706
Q59F91
PDB IDs
1H4L
1LFR
1UNG
1UNH
1UNL
3O0G
4AU8
1L8K
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?