PTPN2

Description		protein tyrosine phosphatase non-receptor type 2
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding STAT Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Negative regulation of MET activity Interleukin-37 signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 25673413) C-reactive protein levels ( 30388399 21300955) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 25489960 28067908 17554261 17554300 21102463) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels in blood ( 25820613) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Psoriasis ( 28537254) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758) Type 1 diabetes ( 21829393 25751624 19430480 17554260 18978792)
Interacting Genes		29 interacting genes: CDK1 CDK2 CDK5 COLEC12 EGFR FAM220A FKBP4 GHR GJB1 HMGB1 INSR ITGA1 JAK1 JAK3 KPNB1 MRPS7 OCLN PDGFRB PTMA SHC1 SRC SRPK1 STAT1 STAT3 STAT5A STAT5B STX17 UBC ZBTB14
Entrez ID		5771
HPRD ID		06768
Ensembl ID		ENSG00000175354
Uniprot IDs		A8K3N4 D3DUJ3 K7EQG9 P17706 Q59F91
PDB IDs		1L8K
Enriched GO Terms of Interacting Partners?
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