ADAM10 and MAP3K8

		ADAM10	MAP3K8
Description		ADAM metallopeptidase domain 10	mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Plasma Membrane Adherens Junction Focal Adhesion Synaptic Vesicle Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Clathrin-coated Vesicle Axon Specific Granule Membrane Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane Pore Complex Extracellular Exosome Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse	Cytosol
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Signaling Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Amyloid-beta Formation Adherens Junction Organization Response To Tumor Necrosis Factor Monocyte Activation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Regulation Of Cell Cycle Regulation Of Dendritic Spine Morphogenesis Cochlea Development Response To Antineoplastic Agent Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Vasculature Development Toxin Transport	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways		Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		XL784
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		9 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 MAP3K8 SH3D19 TCF12 TGFA	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		102	1326
HPRD ID		03723	01863
Ensembl ID		ENSG00000137845	ENSG00000107968
Uniprot IDs		A0A024R5U5 O14672	P41279 Q6FG25
PDB IDs		1M1I 6BDZ 6BE6	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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