SH2D3A and RRM1

		SH2D3A	RRM1
Description		SH2 domain containing 3A	ribonucleotide reductase catalytic subunit M1
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS			Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		9 interacting genes: BCAR1 CENPB EGFR ERBB2 ERBB3 GAB1 ITGB8 NXF1 RRM1	22 interacting genes: BMI1 CDC42 CUZD1 LRIF1 NUP98 PPP1CC PSMD13 RGS4 RNF2 RNH1 RRM2 RRM2B SH2D3A SIRPA SLC22A18 SLC22A18AS SPINK1 STIM1 SUMO2 YWHAG ZFPM2 ZNF655
Entrez ID		10045	6240
HPRD ID		05283	01588
Ensembl ID		ENSG00000125731	ENSG00000167325
Uniprot IDs		A8K2M8 Q9BRG2	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs			2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?
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