RRM1 and RRM2B

Number of citations of the paper that reports this interaction (PubMedID 11517226)
48

Data Source:
HPRD (in vivo)

		RRM1	RRM2B
Description		ribonucleotide reductase catalytic subunit M1	ribonucleotide reductase regulatory TP53 inducible subunit M2B
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Interconversion of nucleotide di- and triphosphates	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine	Cladribine
Diseases
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 32888494)
Interacting Genes		22 interacting genes: BMI1 CDC42 CUZD1 LRIF1 NUP98 PPP1CC PSMD13 RGS4 RNF2 RNH1 RRM2 RRM2B SH2D3A SIRPA SLC22A18 SLC22A18AS SPINK1 STIM1 SUMO2 YWHAG ZFPM2 ZNF655	8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		6240	50484
HPRD ID		01588	05276
Ensembl ID		ENSG00000167325	ENSG00000048392
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	Q7LG56
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?
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